Research Lab Manager
- Email: email@example.com
Monique Heitmeier is utilizing HIV protease inhibitors that inhibit GLUT1 and/or GLU4 as pharmacological tools to determine how altered glucose homeostasis affects disease pathogenesis in mouse models of heart failure and cancer. Current efforts are focused on determining whether altered glucose metabolism affects the unfolded protein/ER stress response in these models, and how modulation of these pathways impacts the observed phenotype.
Rich is investigating structure/function relationships in GLUT1 and GLUT4. He is utilizing state-of-the-art methodologies to perform solution-state structural analysis. A major focus of his current work is to identify and characterize GLUT4 interacting proteins that may regulate the activity and/or cellular trafficking of glucose transporters.
Maria Payne has extensive experience in metabolic measurements in rodents. She is assisting in a number of studies aimed at determining the effects of altered glucose homeostasis on cardiac function. Her current efforts include the study of beneficial effects of incretin hormones in the failing heart.